Novel gammaherpesvirus associated with primary gastric T-cell lymphoma in a free-ranging giant armadillo in Brazil

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Navas-Suarez, Pedro Enrique ; Sacristan, Carlos ; Kluyber, Danilo ; Yogui, Debora Regina ; Alves, Amanda Carolina ; Dalazen, Gislaine Taimara ; Diaz-Delgado, Josue ; Guerra, Juliana Mariotti ; de Azevedo Fernandes, Natalia Coelho Couto ; Ressio, Rodrigo Albergaria ; da Silva, Tereza Cristina ; Cogliati, Bruno ; Desbiez, Arnaud Leonard Jean ; Catao-Dias, Jose Luiz

• Tipo de documento: Artigo Científico
• Fonte: TRANSBOUNDARY AND EMERGING DISEASES; v. 69, n. 4, p. 7-pg., 2021-06-24.

Resumo

The number of viral-associated neoplasms reported in wildlife has increased over the last decades, likely because of growing research efforts and a potentially greater burden of carcinogenic pathogens. Herein, we describe a primary gastric T-cell lymphoma in one free-ranging giant armadillo (Priodontes maximus) from Brazilian Pantanal infected by a novel gammaherpesvirus, proposed as Cingulatid gammaherpesvirus 1 (CiHV-1). By chromogenic in situ hybridisation against Epstein-Barr virus some neoplastic cells were labeled. Subsequently, a molecular screening was carried out to detect the occurrence of this pathogen in other giant armadillos in the same region. Overall, this novel virus was detected in 14.3% (3/21) of the tested giant armadillos. We suggest this herpesvirus, the first in Xenarthra, as a plausible aetiology of the neoplasm. The implications of CiHV-1 for this species are uncertain; while no outbreaks of disease have been recorded, the present study raises concerns. Further research is warranted to assess the real significance of CiHV-1 and its potential oncogenic role in this species. (AU)

• Processo FAPESP: 18/25069-7 - Estudo e caracterização de agentes virais emergentes selecionados e potencialmente associados a hepatopatias em cetáceos costeiros, pelágicos e de habitat misto no Brasil
• Beneficiário: Carlos Sacristan Yague
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/02223-8 - Imunopatologia comparativa da infecção por Morbillivirus nos cetáceos: estudos histológico, imuno-histoquímico e molecular
• Beneficiário: Josué Díaz Delgado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado