Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery

Autor(es)

Meneguin, Andreia Bagliotti ; Barud, Hernane da Silva ; Sabio, Rafael Miguel ; de Sousa, Paula Zanin ; Manieri, Karyn Fernanda ; Pedro de Freitas, Luis Alexandre ; Pacheco, Guilherme ; Alonso, Jovan Duran ; Chorilli, Marlus

• Tipo de documento: Artigo Científico
• Fonte: Carbohydrate Polymers; v. 249, p. 13-pg., 2020-12-01.

Resumo

Defibrillation of bacterial cellulose by ultra-refining was efficient to release nanofibers (BCNF) which were spray dried with the matrices formers mannitol (MN), maltodextrin or hydroxypropylmethylcellulose. The best microsystem comprised the association of BCNF and MN, so the selected microparticles were loaded with diclofenac sodium or caffeine. Depending on the proportion of BCNF, the nanofibers collapse promoted by spray drying can occur onto surface or into microparticles core, leading to different release behaviors. Samples showed pH-dependent drug release, so the microsystem developed with the lowest BCNF concentration showed important trend to gastroresistance. Caffeine was spray dried as a free drug and for this reason it was devoid of any control over release rates. The set of results showed BCNF can be considered an interesting and potential pharmaceutical excipient for lipophilic drugs. Beyond that, BCNF association with MN can lead to novel enteric drug delivery systems based on natural polymers. (AU)

• Processo FAPESP: 18/25512-8 - Plataforma para Cultura de Células Baseada em Biocelulose
• Beneficiário: Hernane da Silva Barud
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/08435-4 - Nanofibras de biocelulose: uma nova geração de materiais para aplicações na liberação de fármacos
• Beneficiário: Andréia Bagliotti Meneguin
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE