| Texto completo | |
| Autor(es): |
Bezzon, Vinicius Danilo Nonato
;
Pinto, Rogerio da Silva
;
de Ara, Gabriel Lima Barros
;
de Lima, Joao Cardoso
;
Ferreira, Fabio Furlan
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Pharmaceutical Sciences; v. 111, n. 11, p. 10-pg., 2022-10-13. |
| Resumo | |
Flubendazole (FBZ) is a poorly water-soluble drug, and different methodologies have been proposed to improve its oral bioavailability. Obtaining the amorphous drug phase is an alternative to improve its water solubility. Several techniques for drug amorphization, such as spray drying, lyophilization, melt quenching, solvent-evaporation, and ball milling, can yield various types of structural disorder and possibly render varia-tions in physicochemical properties. Herein, we focus on evaluating the influence of the ball-milling process on the amorphization of FBZ. The characterization of the average global and local structures before, during, and after the milling process is described by sequential Rietveld refinements, pair distribution function anal-ysis, and the Reverse Monte Carlo method. We show that preserving the local structure (nearest molecules) can be responsible for avoiding the fast structure recrystallization commonly observed when using the sol-vent-evaporation process for the studied drug.(c) 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 18/11990-5 - Caracterização da estrutura local e estabilidade de sistemas amorfos |
| Beneficiário: | Vinícius Danilo Nonato Bezzon |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/04998-2 - Formulações nanocristalinas e dispersões sólidas amorfas para a melhoria de terapias antitumorais |
| Beneficiário: | Gabriel Lima Barros de Araujo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |