Sex under pressure: stress facilitates Leishmania in vitro hybridization

Autor(es)

Monte-Neto, Rubens L. ; Fernandez-Prada, Christopher ; Moretti, Nilmar S.

• Tipo de documento: Artigo Científico
• Fonte: Trends in Parasitology; v. 38, n. 4, p. 3-pg., 2022-03-09.

Resumo

The selection of Leishmania hybrids in axenic culture was considered rare until recently, when Louradour and Ferreira et al., demonstrated that induced DNA damage facilitates genetic exchange, resulting in full genome tetraploid progenies in vitro. Meiosis-related gene homologues HAP2, GEX1, and RAD51 were found to be involved, opening new avenues for functional genomic studies. (AU)

• Processo FAPESP: 18/09948-0 - Estudo da acetilação proteica em Leishmania
• Beneficiário: Nilmar Silvio Moretti
• Modalidade de apoio: Auxílio à Pesquisa - Regular