Protein markers of primary salivary gland tumors: A systematic review of proteomic profiling studies

Autor(es)

de Lima-Souza, Reydson Alcides ; Scarini, Joao Figueira ; Lavareze, Luccas ; Emerick, Carolina ; dos Santos, Erison Santana ; Paes Leme, Adriana Franco ; Abu Egal, Erika Said ; Altemani, Albina ; Mariano, Fernanda Viviane

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 136, p. 13-pg., 2022-02-15.

Resumo

Objective: To integrate all the available data published in the English literature regarding the protein diagnostic and/or prognostic markers in salivary gland tumors identified by mass spectrometry (MS)-based discovery proteomics. Design: An extensive search was carried out using MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases. Manual searching in Google Scholar and assessment of the reference list of the included articles also was performed. The risk of bias was assessed by the Joanna Briggs Institute Critical Appraisal tool for the specific type of study. Results: A total of 1092 articles were initially retrieved within which 6 were used for data extraction, resulting in 145 cases of salivary gland tumors. The data was composted by eleven salivary gland tumor types. In total, 2136 proteins were detected by MS-based discovery proteomics in salivary gland tumors. Ninety-one proteins were proposed as potential diagnostic and/or prognostic markers. Of these, some have been identified in one or more studies, whereas fifteen were in common across studies and a total of seventy-six were non-repeat proteins. Conclusion: In summary, we compiled data about the proteomic profile of potential diagnostic and/or prognostic protein markers of the salivary gland tumors detected by MS-based discovery proteomics. The proteins ANXA1, ANXA5, CAPG, CRYAB, FGB, GNB2L1, IGHG1, PPIA, S100A9, and SOD1 were proposed as the most common potential diagnostic markers of salivary gland tumors. (AU)

• Processo FAPESP: 19/06809-2 - Análise de espectrometria de massa na transformação maligna do adenoma pleomorfo. correlação de dados com expressão gênica e exoma
• Beneficiário: Reydson Alcides de Lima Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/19922-9 - Análise proteômica dos fluidos lacrimais em pacientes com lesões orais potencialmente malignas e câncer de boca
• Beneficiário: Erison Santana dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/09419-0 - Alterações genômicas na transformação maligna do Adenoma Pleomorfo
• Beneficiário: João Figueira Scarini
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores