The adaptation of maternal energy metabolism to lactation and its underlying mechanisms

Autor(es)

Anhe, Gabriel Forato ; Bordin, Silvana

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Endocrinology; v. 553, p. 22-pg., 2022-06-11.

Resumo

ABSTR A C T Maternal energy metabolism undergoes a singular adaptation during lactation that allows for the caloric enrichment of milk. Changes in the mammary gland, changes in the white adipose tissue, brown adipose tissue, liver, skeletal muscles and endocrine pancreas are pivotal for this adaptation. The present review details the landmark studies describing the enzymatic modulation and the endocrine signals behind these metabolic changes. We will also update this perspective with data from recent studies showing transcriptional and post-transcriptional mechanisms that mediate the adaptation of the maternal metabolism to lactation. The present text will also bring experimental and observational data that describe the long-term consequences that short periods of lactation impose to maternal metabolism. (AU)

• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 20/13940-5 - Impactos da história transitória de obesidade em diferentes momentos da vida sobre a inflamação pulmonar alérgica
• Beneficiário: Gabriel Forato Anhê
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/03196-0 - Mecanismos moleculares envolvidos na inflexibilidade metabólica de ratos submetidos à programação fetal por excesso de glicocorticoides
• Beneficiário: Silvana Auxiliadora Bordin da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular