Red propolis exhibits chemopreventive effect associated with antiproliferative and anti-inflammatory activities

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de Freitas, Karoline Soares ; Domingos da Silva, Lucas Henrique ; Squarisi, Iara Silva ; de Souza Oliveira, Lucas Teixeira ; Ribeiro, Arthur Barcelos ; Alves, Bianca Silva ; Esperandim, Tabata Rodrigues ; Santos de Melo, Matheus Reis ; Ozelin, Saulo Duarte ; Lemes, Danieli Cristina ; Bastos, Jairo Kenupp ; Sola Veneziani, Rodrigo Cassio ; Tavares, Denise Crispim

• Tipo de documento: Artigo Científico
• Fonte: TOXICOLOGY RESEARCH; v. 11, n. 5, p. 8-pg., 2022-08-23.

Resumo

INTRODUCTION: Red propolis is synthetized from exudates of Dalbergia ecastophyllum (L) Taub. and Symphonia globulifera L.f., presents isoflavones, guttiferone E, xanthochymol, and oblongifolin B and has anti-inflammatory, antioxidant, and antiproliferative activities. OBJECTIVES: This study aimed to evaluate the antigenotoxic and anticarcinogenic potential of red propolis hydroalcoholic extract (RPHE) in rodents. METHODS: The influence of RPHE in doxorubicin (DXR)-induced genotoxicity was investigated through the micronucleus test in Swiss mice. Blood samples were also collected to investigate oxidative stress, hepatotoxicity, and nephrotoxicity. Was investigated the influence of RPHE in 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci, as well as its influence in proliferating cell nuclear antigen (PCNA) and the cyclooxygenase-2 (COX-2) expression in colon of rats, by immunohistochemistry. RESULTS: The results showed that RPHE (48 mg/kg) reduced DXR-induced genotoxicity. Animals treated with DXR showed significantly lower GSH serum levels in comparison to the negative control. RPHE treatments did not attenuated significantly the DXR-induced GSH depletion. No difference was observed in cytotoxicity parameters of mice hematopoietic tissues between the treatment groups, as well as the biochemical parameters of hepatotoxicity and nephrotoxicity. RPHE (12 mg/kg) reduced the DMH-induced carcinogenicity and toxicity, as well as DMH-induced PCNA and COX-2 expression in colon tissue. CONCLUSION: Therefore, was observed that the RPHE has chemopreventive effect, associated to antiproliferative and anti-inflammatory activities. (AU)

• Processo FAPESP: 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/02370-3 - Avaliação do potencial quimiopreventivo do extrato hidroalcoólico da própolis vermelha brasileira
• Beneficiário: Karoline Soares de Freitas
• Modalidade de apoio: Bolsas no Brasil - Mestrado