Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry

Autor(es)

Soares, Guilherme A. ; Pereira, Gabriele M. ; Romualdo, Guilherme R. ; Biasotti, Gabriel G. A. ; Stoppa, Erick G. ; Bakuzis, Andris F. ; Baffa, Oswaldo ; Barbisan, Luis F. ; Miranda, Jose R. A.

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICS; v. 14, n. 9, p. 19-pg., 2022-09-01.

Resumo

Since magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose and treat liver diseases in recent years, this study aimed to assess how the condition of cirrhosis-associated hepatocarcinogenesis alters the biodistribution of hepatic MNPs. Using a real-time image acquisition approach, the distribution profile of MNPs after intravenous administration was monitored using an AC biosusceptometry (ACB) assay. We assessed the biodistribution profile based on the ACB images obtained through selected regions of interest (ROIs) in the heart and liver position according to the anatomical references previously selected. The signals obtained allowed for the quantification of pharmacokinetic parameters, indicating that the uptake of hepatic MNPs is compromised during liver cirrhosis, since scar tissue reduces blood flow through the liver and slows its processing function. Since liver monocytes/macrophages remained constant during the cirrhotic stage, the increased intrahepatic vascular resistance associated with impaired hepatic sinusoidal circulation was considered the potential reason for the change in the distribution of MNPs. (AU)

• Processo FAPESP: 21/06405-9 - Modelos in vitro e in vivo para avaliação do perfil de absorção e internalização de nanopartículas magnéticas para potencial aplicação biomédica
• Beneficiário: Guilherme Augusto Soares
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/11277-0 - Mapeamento da distribuição de nanopartículas magnéticas em modelo de carcinoma hepatocelular através de imagens magnéticas
• Beneficiário: Gabriele Martins Pereira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 21/09829-4 - Biosusceptometria AC: modelos, instrumentações e aplicações
• Beneficiário: José Ricardo de Arruda Miranda
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs