Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array

Autor(es)

Soares, Guilherme ; Pinto, Leonardo ; Liebl, Maik ; Biasotti, Gabriel ; Prospero, Andre ; Stoppa, Erick ; Bakuzis, Andris ; Baffa, Oswaldo ; Wiekhorst, Frank ; Arruda Miranda, Jose Ricardo

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOLOGICAL ENGINEERING; v. 16, n. 1, p. 11-pg., 2022-10-11.

Resumo

Background Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB), the magnetic nanoparticle's magnetization response under an oscillating magnetic field, which is applied through an excitation coil, is detected with a balanced detection coil system. Results We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic nanoparticles spatial distributions in a field of view of 14 x 14 cm(2) with a spatial resolution of 2.0 cm and sensitivity in the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle distributions above 0.6 was found for all measurements. Conclusion Besides other interesting features such as sufficient large field of view dimension for mice and rat studies, portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an affordable setup for easy access in clinical or laboratory environments. (AU)

• Processo FAPESP: 21/09829-4 - Biosusceptometria AC: modelos, instrumentações e aplicações
• Beneficiário: José Ricardo de Arruda Miranda
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/11277-0 - Mapeamento da distribuição de nanopartículas magnéticas em modelo de carcinoma hepatocelular através de imagens magnéticas
• Beneficiário: Gabriele Martins Pereira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs