| Texto completo | |
| Autor(es): Mostrar menos - |
Carneiro, Camila de Godoi
;
Faria, Daniele de Paula
;
Coutinho, Artur Martins
;
Ono, Carla Rachel
;
Duran, Fabio Luis de Souza
;
da Costa, Naomi Antunes
;
Garcez, Alexandre Teles
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da Silveira, Paula Squarzoni
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Forlenza, Orestes Vicente
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Brucki, Sonia Maria Dozzi
;
Nitrini, Ricardo
;
Busatto Filho, Geraldo
;
Buchpiguel, Carlos Alberto
Número total de Autores: 13
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| Tipo de documento: | Artigo Científico |
| Fonte: | Revista Brasileira de Psiquiatria; v. 44, n. 5, p. 12-pg., 2022-09-01. |
| Resumo | |
Objective: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer's disease. Mild cognitive impairment is an intermediate stage between normal cognition and Alzheimer-type dementia. In vivo fibrillar amyloid-beta can be detected in PET using [11C]-labeled Pittsburgh compound B (11C-PiB). In contrast, [18F] fluoro-2-deoxy-d-glucose (18F-FDG) is a neurodegeneration biomarker used to evaluate cerebral glucose metabolism, indicating neuronal injury and synaptic dysfunction. In addition, early cerebral uptake of amyloid-PET tracers can determine regional cerebral blood flow. The present study compared early-phase 11C-PiB and 18F-FDG in older adults without cognitive impairment, amnestic mild cognitive impairment, and clinical diagnosis of probable Alzheimer's disease.Methods: We selected 90 older adults, clinically classified as healthy controls, with amnestic mild cognitive impairment, or with probable Alzheimer's disease, who underwent an 18F-FDG PET, early -phase 11C-PiB PET and magnetic resonance imaging. All participants were also classified as amyloid-positive or-negative in late-phase 11C-PiB. The data were analyzed using statistical parametric mapping.Results: We found that the probable Alzheimer's disease and amnestic mild cognitive impairment group had lower early-phase 11C-PiB uptake in limbic structures than 18F-FDG uptake. The images showed significant interactions between amyloid-beta status (negative or positive). However, early -phase 11C-PiB appears to provide different information from 18F-FDG about neurodegeneration.Conclusions: Our study suggests that early-phase 11C-PiB uptake correlates with 18F-FDG, irrespective of the particular amyloid-beta status. In addition, we observed distinct regional distribution patterns between both biomarkers, reinforcing the need for more robust studies to investigate the real clinical value of early-phase amyloid-PET imaging. (AU) | |
| Processo FAPESP: | 12/50329-6 - Neurociência translacional da doença de Alzheimer: estudos pré-clínicos e clínicos do peptídeo b-amiloide e outros biomarcadores |
| Beneficiário: | Geraldo Busatto Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |