Effect of laser thermochemical treatment of Ti-6Al-4V alloy on Candida albicans biofilm growth

Autor(es)

Santa Maria Godoy, Gabrielle G. ; de Andrade, Vitor Martins ; Dondeo, Fabio ; Conceicao, Katia ; Capella, Aline

• Tipo de documento: Artigo Científico
• Fonte: Materials Chemistry and Physics; v. 294, p. 9-pg., 2023-01-15.

Resumo

Candida albicans is an opportunistic fungal pathogen that colonizes many human mucosal and is the major infectious specie in biomedical devices. Although Ti and its alloys have been used to manufacture biomedical devices, some drawbacks can allow the attachment fungi and/or bacteria. The thermochemical treatment by lasers of the metallic materials is attractive strategies to improve the antimicrobial properties of their surfaces. In this study, thermochemical treatment by laser were performed on Ti-6Al-4V sample. Its microstructural char-acterization by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), roughness profile, and X-ray diffraction (XRD) revealed the morphological changes of the laser-treated surfaces with for-mation of TiN, besides TiO2. Antimicrobial assays were performed against C. albicans fungi. It was found that laser processing route produced inhibitory potential of C. albicans biofilm on treated surfaces, with almost complete inhibition of biofilm (20% of viable cells). Thus, the thermochemical treatment by laser is a potential tool for surface modification of Ti alloy to be employed in biomedical components. (AU)

• Processo FAPESP: 20/07819-9 - Texturização a laser de Ti-6Al-4V para inibição de crescimento de biofilme
• Beneficiário: Gabrielle Garcia Santa Maria
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica