Meta-Chlorophenylpiperazine-Induced Behavioral Changes in Obsessive-Compulsive Disorder Research: A Systematic Review of Rodent Studies

Autor(es)

da Silva, Jessica Fernandes ; Taguchi, Leticia Mitsuko ; Leite, Erinete da Silva ; de Oliveira, Amanda Ribeiro

• Tipo de documento: Artigo Científico
• Fonte: Neuroscience; v. 507, p. 14-pg., 2022-12-10.

Resumo

Meta-chlorophenylpiperazine (mCPP) was one of the first compounds used in clinical and preclinical studies that demonstrated the role of serotonin in Obsessive-Compulsive Disorder (OCD). This systematic review aimed to (a) identify publications that report in rodents the effects of mCPP relevant to OCD, (b) explore the methodological characteristics of these studies, and (c) summarize the profile of mCPP effects. A comprehensive literature search was performed using PubMed, Scopus, and Web of Science. Search terms were a combination of obsessive-compulsive disorder or OCD and meta-chlorophenylpiperazine or mCPP. Twenty-nine articles were included in the review. The years of publication ranged from 1993 to 2021. Most studies used adult male Wistar or Sprague-Dawley rats. The most frequent dose of mCPP was 1.0 mg/kg administered acutely, intraperitoneally. In general, available preclinical evidence suggests increased defensive and compulsive behaviors associated with a decreased locomotor activity. But other results besides these and the absence of significant mCPP effects were also observed. Among the factors that may contribute to the variability of mCPP effects, differences in meth-ods are highlighted, such as characteristics of the species/strains studied, mCPP doses and treatment regimens used. The heterogeneity of the OCD-like behaviors evaluated and the interaction of mCPP with different receptors may also be critical variables for discrepancies in the findings with mCPP. The information described in this review may contribute to a better understanding of how mCPP-induced behavioral changes in rodents have been used to study OCD, highlighting the main challenges for future investigations in this field.(c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 19/04351-9 - Efeitos da meta-clorofenilpiperazina (mCPP) sobre a autolimpeza e alternância espontânea em ratos: influências do sexo e do ciclo estral
• Beneficiário: Leticia Mitsuko Taguchi
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/02730-2 - Efeitos da meta-clorofenilpiperazina (mCPP) na indução de comportamentos do tipo compulsivo em ratas: influência do ciclo estral
• Beneficiário: Jéssica Fernandes da Silva
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/02255-7 - Relações entre a autolimpeza induzida por meta-clorofenilpiperazina (mCPP) e os comportamentos de checagem compulsiva e alternância espontânea em ratos
• Beneficiário: Leticia Mitsuko Taguchi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica