C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis

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Picelli de Azevedo, Maria Gabriela ; Geraldes, Silvano Salgueiro ; Sant'Anna, Paula Bilbau ; Batista, Beatriz Poloni ; Maia, Suellen Rodrigues ; de Moraes, Reiner Silveira ; Dos Santos Schmidt, Elizabeth Moreira ; de Souza, Fabiana Ferreira ; Melchert, Alessandra ; Pinheiro Ferreira, Joao Carlos ; Dadalto, Carmel Rezende ; Mogollon Garcia, Henry David ; Chalfun Guimaraes-Okamoto, Priscylla Tatiana

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 17, n. 9, p. 13-pg., 2022-09-22.

Resumo

In chronic kidney disease dogs, the inflammatory process increases C-reactive protein concentrations. This study aimed to determine C-reactive protein serum concentrations in stage IV chronic kidney disease dogs treated with intermittent hemodialysis. A prospective cohort study was conducted with 23 dogs allocated into three groups: control group (CG, n = 7), intermittent hemodialysis group (IHG, n = 8) and clinical treatment group (CTG, n = 8), both comprised of stage IV chronic kidney disease dogs. One blood sample from CG (initial evaluation) and two samples from IHG and CTG (first- and last-moment) were obtained to determine C-reactive protein concentration, total leukocytes, platelets, erythrocytes, total plasma protein, serum albumin, urea, creatinine, and phosphorus. C-reactive protein was higher in IHG compared to CG in the first- and last-moments (p <0.001) and compared to CTG in the first-moment (p = 0.0406). C-reactive protein presented moderate positive correlation with leukocytes (r = 0.5479; p = 0.01), and moderate negative correlation with albumin (r = - 0.5974; p = 0.006) and red blood cells (r = - 0.5878, p = 0.01). A high correlation coefficient was observed in the tests' evaluation (CI = 0.59-0.78; r = 0.70; P<0.0001). In conclusion, both assays used in this study to measure C-reactive protein have provided safe and reliable quantification of the results. Additionally, despite IHG dogs presented an active inflammatory profile, intermittent hemodialysis has proven to be beneficial, leading to a clinical improvement in life quality of patients, and thus being recommended for stage IV CKD dogs when performed by trained professionals. (AU)

• Processo FAPESP: 13/02932-8 - Efeitos da hemodiálise intermitente em fase precoce da doença renal crônica sobre o perfil clínico e laboratorial de cães atendidos no serviço de clínica médica de pequenos animais da FMVZ-UNESP, Botucatu
• Beneficiário: Priscylla Tatiana Chalfun Guimaraes-Okamoto
• Modalidade de apoio: Auxílio à Pesquisa - Regular