Characterization and in vivo toxicological evaluation of multi-walled carbon nanotubes: a low-dose repeated intratracheal administration study

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Bubols, Guilherme Borges ; Arbo, Marcelo Dutra ; Peruzzi, Caroline Portela ; Cestonaro, Larissa Vivan ; Altknecht, Louise Figueiredo ; Fao, Nuryan ; Goethel, Gabriela ; Nascimento, Sabrina Nunes ; Paese, Karina ; Amaral, Marta Goncalves ; Bergmann, Carlos Perez ; Pohlmann, Adriana Raffin ; Guterres, Silvia Staniscuaski ; Garcia, Solange Cristina

• Tipo de documento: Artigo Científico
• Fonte: Environmental Science and Pollution Research; v. N/A, p. 17-pg., 2022-12-22.

Resumo

This study characterized and investigated the toxicity of two multi-walled carbon nanotubes (MWCNT) NM-401 and NM-403 at 60 and 180 mu g after four repeated intratracheal instillations; follow-up times were 3, 7, 30, and 90 days after the last instillation. NM-401 was needle-like, long, and thick, while NM-403 was entangled, short, and thin. Both MWCNT types induced transient pulmonary and systemic alterations in renal function and oxidative lipid damage markers in recent times. Animals showed general toxicity in the immediate times after exposures, in addition to increased pulmonary LDH release at day 3. In further times, decreased liver and kidney relative weights were noted at higher MWCNT doses. Lung histological damages included pulmonary fibrosis, for both MWCNT types, similarly to asbestos; single liver and kidney histological alterations were present. Repeated instillations led to persistent pulmonary damage at low doses, and possibly the extrapulmonary effects may be associated with the consecutive exposures. (AU)

• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático