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Paracoccidioides and Paracoccidioidomycosis in the 21st Century

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Autor(es):
Rodrigues, Anderson Messias ; Hagen, Ferry ; Puccia, Rosana ; Hahn, Rosane Christine ; de Camargo, Zoilo Pires
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: Mycopathologia; v. N/A, p. 5-pg., 2023-01-12.
Resumo

Paracoccidioidomycosis (PCM) defines a broad spectrum of human and animal diseases caused by Paracoccidioides species (Onygenales). In the twenty-first century, Paracoccidioides advanced from a monotypic taxon to a genus that harbors seven species, including P. brasiliensis sensu stricto, P. americana, P. restrepiensis, P. venezuelensis, P. lutzii, P. loboi, and P. cetii. Classic PCM, acquired upon inhalation of propagules from P. brasiliensis sensu stricto, P. americana, P. restrepiensis, P. venezuelensis, and P. lutzii, affects the human lungs and may progress to systemic granulomatous disease with tegumentary and visceral involvement. On the other hand, PCM loboi and PCM ceti caused by the unculturable P. loboi and P. cetii are subcutaneous mycoses, typically observed as keloid lesions in humans and dolphins. Such heterogeneity highlights the importance of recognizing species boundaries in Paracoccidioides to gain insights into the ecology, evolution, clinical features, and mitigation strategies to tackle the advance of PCM. (AU)

Processo FAPESP: 17/27265-5 - Epidemiologia molecular e perspectivas genômicas na evolução e propagação de patógenos fúngicos emergentes
Beneficiário:Anderson Messias Rodrigues
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores