Osseointegration of implants with superhydrophilic surfaces in rats with high serum levels of nicotine

Autor(es)

Felipe Eduardo Pinotti ^[1] ; Maurício Andrés Tinajero Aroni ^[2] ; Guilherme José Pimentel Lopes de Oliveira ^[3] ; Bruno Luís Graciliano Silva ^[4] ; Elcio Marcantonio Junior ^[5] ; Rosemary Adriana Chiérici Marcantonio ^[6]

Afiliação do(s) autor(es)

^[1] São Paulo State University. School of Dentistry - Brasil

^[2] San Francisco de Quito University - Equador

^[3] Universidade Federal de Uberlândia. School of Dentistry - Brasil

^[4] São Paulo State University. School of Dentistry - Brasil

^[5] São Paulo State University. School of Dentistry - Brasil

^[6] São Paulo State University. School of Dentistry - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 34, n. 2, p. 105-112, 2023-05-15.

Resumo

Abstract This study aimed to evaluate the effect of nicotine administration on the osseointegration of a superhydrophilic implants surface on rat tibiae. Thirty-two rats were used and divided into 2 groups according to the administration or not of nicotine: HH - Installation of implants with superhydrophilic surfaces in healthy animals; and HN - Installation of implants with superhydrophilic surfaces in animals subjected to nicotine administration. The animals were euthanized 15 and 45 days after implant placement (n = 8). Osseointegration was assessed by means of biomechanical analyses (removal torque), microcomputed tomography (volume of bone around the implants- %BV/TV), and histomorphometry (bone-implant contact -%BIC and the bone area between implant threads -%BBT). The animals subject to the nicotine administration presented lower removal torque than the control animals at the 45-day period (21.88 ± 2.80 Ncm vs. 17.88 ± 2.10 Ncm). The implants placed in the control rats presented higher %BIC (54.26 ± 6.59% vs. 39.25 ± 4.46%) and %BBT (50.57 ± 5.28% vs. 32.25 ± 5.24%) than the implants placed in nicotine animals at 15-day period. The nicotine administration reduces the osseointegration at 15 days, however, the superhydrophilic surface equalized the osseointegration in nicotine-exposed animals compared with healthy animals after 45 days of implant placement. (AU)

• Processo FAPESP: 18/01610-0 - Avaliação da osseointegração de implantes ACQUA em ratos com comprometimento sistêmico
• Beneficiário: Felipe Eduardo Pinotti
• Modalidade de apoio: Bolsas no Brasil - Doutorado