The use of omega-3 fatty acids in the treatment of oral diseases

Autor(es)

Azuma, Mariane Maffei ; Morais Cardoso, Carolina de Barros ; da Silva, Cristiane Cantiga ; de Oliveira, Pedro Henrique Chaves ; Jacinto, Rogerio de Castilho ; Andrada, Ana Cristina ; Cintra, Luciano Tavares Angelo

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 28, n. 2, p. 11-pg., 2020-10-27.

Resumo

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been reported to exert important roles in the inflammatory response. There are many inflammatory diseases in dentistry which support the administration of omega-3 PUFAs as an adjunct therapy during the treatment of these diseases. The aim of this review was to evaluate the use of omega-3 PUFAs as an adjuvant therapy during the treatment of buccal diseases. The review showed that supplementation with omega-3 PUFAs was used for treatment of gingivitis, periodontal diseases, apical periodontitis, stomatitis, and orthodontic tooth movement. The results indicate that omega-3 PUFAs decreased the number of pro-inflammatory mediators in the gingival tissues of individuals with gingivitis and periodontitis. In apical periodontitis, the supplementation suppressed bone resorption and promoted bone formation in the periapical area of rats. During orthodontic movement, the supplementation showed a decrease of bone resorption in rats. It also showed that painful symptoms of recurrent aphthous stomatitis were alleviated in supplemented patients. In conclusion, the omega-3 PUFAs may be used as an adjuvant therapy in the treatment of inflammatory diseases that affect the oral cavity. However, more studies are required to elucidate the role of omega-3 PUFAs in decreasing oral cavity inflammatory processes. (AU)

• Processo FAPESP: 15/03054-0 - Efeito da suplementação alimentar com o ácido graxo ômega 3 nos níveis de triglicérides e na reabsorção óssea de ratos Wistar com infecção endodôntica
• Beneficiário: Carolina de Barros Morais Cardoso
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/26390-0 - Influência local e sistêmica da suplementação alimentar com o ácido graxo ômega-3 em ratos com infecção endodôntica
• Beneficiário: Mariane Maffei Azuma
• Modalidade de apoio: Bolsas no Brasil - Doutorado