Autor(es)

Pegorin, Giovana S. ; Leite, Marcel N. ; Antoniassi, Marcio ; Chagas, Ana Laura D. ; Santana, Luisiane A. ; Garms, Bruna C. ; Marcelino, Monica Y. ; Herculano, Rondinelli D. ; Cipriani Frade, Marco Andrey

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 109, n. 7, p. 11-pg., 2020-11-25.

Resumo

Skin wounds have been a public health concern of high frequency, in addition to requiring intensive and expensive care. The natural rubber latex (NRL) from Hancornia speciosa Gomes has been used to treat many problems in traditional medicine and also present healing properties, antifungal and anti-inflammatory activity and antinociceptive effects. The purpose of this study was to characterize the new biomembrane from the NRL of H. speciosa (HS) by Fourier transform infrared (FTIR) and mechanical strength test and to investigate its biological properties by the cytotoxicity assay and in vivo healing activity. The results showed that the HS biomembrane exhibited characteristic bands of the main component cis-1,4-polyisoprene. Besides, its Young modulus was close to human skin with adhesive-compatible mechanical characteristics. The cytotoxicity assays revealed that the HS biomembrane was not toxic to fibroblast cells neither using agar diffusion test nor MTT assay. Furthermore, the HS biomembrane stimulated the inflammatory cells and the angiogenesis, increased significantly the collagenesis and improved the quality of heal until the remodeling phase induced by implants in mice. Thus, this biomembrane has proven to be a safe and biocompatible biomaterial with healing potential, becoming an effective and low-cost alternative for the treatment of skin wounds. (AU)

• Processo FAPESP: 09/09355-0 - Biomembrana de látex natural da seringueira Hevea brasiliensis e oncostatina M na cicatrização de úlceras cutâneas em ratos diabéticos
• Beneficiário: Marco Andrey Cipriani Frade
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/16437-7 - Avaliação da viabilidade do modelo de pele humana ex vivo (hOSEC) e sua aplicação em estudos de eficácia de protetores solares a longo prazo no fotoenvelhecimento
• Beneficiário: Marco Andrey Cipriani Frade
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/19603-8 - Desenvolvimento de um novo adesivo à base de látex natural reforçado com barbatimão e suas frações e estudo das vias de sinalização do reparo dérmico
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Regular