Mitochondrial connections with immune system in Zebrafish

Autor(es)

do Amaral, Mariana Abrantes ; Paredes, Lais Cavalieri ; Padovani, Barbara Nunes ; Mendonca-Gomes, Juliana Moreira ; Montes, Luan Favero ; Saraiva Camara, Niels Olsen ; Fenero, Camila Morales

• Tipo de documento: Artigo Científico
• Fonte: FISH AND SHELLFISH IMMUNOLOGY REPORTS; v. 2, p. 11-pg., 2021-12-01.

Resumo

Mitochondria are organelles commonly associated with adenosine triphosphate (ATP) formation through the oxidative phosphorylation (OXPHOS) process. However, mitochondria are also responsible for functions such as calcium homeostasis, apoptosis, autophagy, and production of reactive oxygen species (ROS) that, in conjunction, can lead to different cell fate decisions. Mitochondrial morphology changes rely on nutrients' availability and the bioenergetics demands of the cells, in a process known as mitochondrial dynamics, which includes both fusion and fission. This organelle senses the microenvironment and can modify the cells to either a pro or anti-inflammatory profile. The zebrafish has been increasingly used to research mitochondrial dynamics and its connection with the immune system since the pathways and molecules involved in these processes are conserved on this fish. Several genetic tools and technologies are currently available to analyze the behavior of mitochondria in zebrafish. However, even though zebrafish presents several similar processes known in mammals, the effect of the mitochondria in the immune system has not been so broadly studied in this model. In this review, we summarize the current knowledge in zebrafish studies regarding mitochondrial function and immuno metabolism. (AU)

• Processo FAPESP: 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/21644-9 - Inflamação induzida pela obesidade, alterações da microbiota e seus efeitos no sistema nervoso entérico: estudo num modelo experimental de zebrafish.
• Beneficiário: Camila Idelí Morales Fénero
• Modalidade de apoio: Bolsas no Brasil - Doutorado