| Texto completo | |
| Autor(es): |
Luiz, Marcela Tavares
;
Dutra, Jessyca Aparecida Paes
;
Viegas, Juliana Santos Rosa
;
de Araujo, Jennifer Thayanne Cavalcante
;
Tavares Junior, Alberto Gomes
;
Chorilli, Marlus
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACEUTICS; v. 15, n. 3, p. 21-pg., 2023-03-01. |
| Resumo | |
Cancer is one of the major public health problems worldwide. Despite the advances in cancer therapy, it remains a challenge due to the low specificity of treatment and the development of multidrug resistance mechanisms. To overcome these drawbacks, several drug delivery nanosystems have been investigated, among them, magnetic nanoparticles (MNP), especially superparamagnetic iron oxide nanoparticles (SPION), which have been applied for treating cancer. MNPs have the ability to be guided to the tumor microenvironment through an external applied magnetic field. Furthermore, in the presence of an alternating magnetic field (AMF) this nanocarrier can transform electromagnetic energy in heat (above 42 degrees C) through Neel and Brown relaxation, which makes it applicable for hyperthermia treatment. However, the low chemical and physical stability of MNPs makes their coating necessary. Thus, lipid-based nanoparticles, especially liposomes, have been used to encapsulate MNPs to improve their stability and enable their use as a cancer treatment. This review addresses the main features that make MNPs applicable for treating cancer and the most recent research in the nanomedicine field using hybrid magnetic lipid-based nanoparticles for this purpose. (AU) | |
| Processo FAPESP: | 21/04007-6 - Avaliação do potencial de imunolipossomas e imunomagnetolipossomas contendo epirrubicina funcionalizados com trastuzumabe no tratamento do câncer de mama |
| Beneficiário: | Marcela Tavares Luiz |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |