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Impact of Mesoporous Silica Functionalization Fine-Tuning on Antibiotic Uptake/Delivery and Bactericidal Activity

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Autor(es):
Bouchmella, Karim ; Lion, Quentin ; Gervais, Christel ; Cardoso, Mateus Borba
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: ACS OMEGA; v. 8, n. 13, p. 11-pg., 2023-03-22.
Resumo

The mesoporous SBA-15 material was surface-functionalized with amino and carboxylic acid groups and used as a platform to investigate the interaction of these chemical groups with tetracycline, kanamycin, and ampicillin antibiotics. The interactions between the antibiotic and the functionalized surfaces were characterized using two-dimensional 1H-13C HETCOR CP MAS and FTIR spectroscopy and indicated that -COO-NH3+ bondings had been formed between chemical groups on the silica surface and drug molecules. The surface modification resulted in higher kanamycin and ampicillin loadings and a slow-release rate, and all synthesized systems showed antibacterial activity against susceptible Escherichia coli bacteria. Almost total death of bacteria was obtained using a few ppm of tetracycline-and kanamycin-loaded systems, whereas the ampicillin-loaded one showed lower bactericidal activity than free ampicillin. (AU)

Processo FAPESP: 21/12071-6 - Arquitetando coloides via interações supramoleculares: de fundamentos a aplicações
Beneficiário:Watson Loh
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas
Beneficiário:Watson Loh
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/22322-2 - Funcionalização de nanopartículas de sílica: aumentando a interação biológica
Beneficiário:Mateus Borba Cardoso
Modalidade de apoio: Auxílio à Pesquisa - Regular