Carotid intima-media thickness in adults with and without psoriasis - a nested case-control study from baseline data of ELSA-Brasil cohort

Autor(es)

Tebar, William R. ; Santos, Itamar de S. ; Meneghini, Vandrize ; Bittencourt, Marcio Sommer ; Lotufo, Paulo A. ; Bensenor, Isabela M.

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING; v. 39, n. 8, p. 9-pg., 2023-06-08.

Resumo

There is a lack of consensus about the association between psoriasis (PSO) and carotid intima-media thickness (cIMT) in literature, since previous studies considered dermatologic clinic patients or general population. This study aimed to compare cIMT levels according to PSO in a sample of 10,530 civil servants form the ELSA-Brasil cohort study and analyze its association with the disease. The PSO cases and disease duration were identified by medical diagnosis self-reported at study enrollment. A paired group was identified by propensity score matching among all the participants without PSO. Mean cIMT values were considered for continuous analysis while cIMT above 75th percentile was considered for categorical analysis. Multivariate conditional regression models were used to analyze association between cIMT and PSO diagnosis, by comparing PSO cases against paired controls and overall sample without disease. A total of n = 162 PSO cases were identified (1.54%) and no difference in cIMT values was observed between participants with PSO and overall sample or control group. PSO was not associated with linear increment of cIMT (vs. overall sample: beta = 0.003, p = 0.690; vs. matched controls: beta = 0.004, p = 0.633) neither with increased chance of having cIMT above 75th percentile (vs. overall sample: OR = 1.06, p = 0.777; vs. matched controls: OR = 1.19, p = 0.432; conditional regression: OR = 1.31, p = 0.254). There was no relationship between disease duration and cIMT (beta = 0.000, p = 0.627). Although no significant relationship between mild cases of psoriasis and cIMT was observed among a wide cohort of civil servants, longitudinal investigation about cIMT progression and severity of disease are still needed. (AU)

• Processo FAPESP: 19/23734-6 - Doenças inflamatórias crônicas e mortalidade geral, por doença cardiovascular e outras causas: associação com fatores de risco, Aterosclerose subclínica e eventos cardiovasculares fatais e não fatais no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
• Beneficiário: Isabela Judith Martins Bensenor
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/04416-3 - Associação de Lúpus, Síndrome de Sjögren, Vasculites, Doença Celíaca e Psoríase com escore de cálcio na linha de base e incidência/progressão de escore de cálcio, mortalidade geral e por doença cardiovascular no seguimento de 8 anos do ELSA-Brasil
• Beneficiário: William Rodrigues Tebar
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/06798-0 - Doença tireoidiana autoimune e doenças inflamatórias: associação com a Aterosclerose subclínica e com mortalidade geral e por doenças cardiovasculares no ELSA-Brasil
• Beneficiário: Vandrize Meneghini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado