Past, present, and future of chemically induced hepatocarcinogenesis rodent models: Perspectives concerning classic and new cancer hallmarks

Autor(es)

Romualdo, Guilherme Ribeiro ; Heidor, Renato ; Bacil, Gabriel Prata ; Moreno, Fernando Salvador ; Barbisan, Luis Fernando

• Tipo de documento: Artigo Científico
• Fonte: Life Sciences; v. 330, p. 16-pg., 2023-10-01.

Resumo

Hepatocellular carcinoma (HCC), the main primary liver cancer, accounts for 5 % of all incident cases and 8.4 % of all cancer-related deaths worldwide. HCC displays a spectrum of environmental risk factors (viral chronic infections, aflatoxin exposure, alcoholic-and nonalcoholic fatty liver diseases) that result in molecular complexity and heterogeneity, contributing to a rising epidemiological burden, poor prognosis, and non-satisfactory treatment options. The emergence of HCC (i.e., hepatocarcinogenesis) is a multistep and complex process that addresses many (epi)genetic alterations and phenotypic traits, the so-called cancer hallmarks. "Polymorphic microbiomes", "epigenetic reprogramming", "senescent cells" and "unlocking phenotypic plas-ticity" are trending hallmarks/enabling features in cancer biology. As the main molecular drivers of HCC are still undruggable, chemically induced in vivo models of hepatocarcinogenesis are useful tools in preclinical research. Thus, this narrative review aimed at recapitulating the basic features of chemically induced rodent models of hepatocarcinogenesis, eliciting their permanent translational value regarding the "classic" and the "new" cancer hallmarks/enabling features. We gathered state-of-art preclinical evidence on non-cirrhotic, inflammation-, alcoholic liver disease-and nonalcoholic fatty liver-associated HCC models, demonstrating that these bioassays indeed express the recently added hallmarks, as well as reflect the interplay between classical and new cancer traits. Our review demonstrated that these protocols remain valuable for translational preclinical application, as they recapitulate trending features of cancer science. Further "omics-based" approaches are warranted while multimodel investigations are encouraged in order to avoid "model-biased" responses. (AU)

• Processo FAPESP: 23/08751-7 - Multimodel Drug Screening Platform (MDSP): insights pré-clínicos e moleculares para o gerenciamento dos cânceres de cólon e fígado
• Beneficiário: Guilherme Ribeiro Romualdo
• Modalidade de apoio: Bolsas no Brasil - Projeto Geração
• Processo FAPESP: 22/16633-1 - Carboximetilcelulose e Polissorbato 80: efeitos de aditivos alimentares sobre a hepatocarcinogênese associada à Doença Hepática não Alcoólica
• Beneficiário: Luís Fernando Barbisan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/13402-9 - Efeitos dos aditivos alimentares carboximetilcelulose e polissorbato 80 sobre o processo de hepatocarcinogênese associada à doença hepática gordurosa não-alcoólica
• Beneficiário: Gabriel Bacil Prata
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/06082-8 - Multimodel Drug Screening Platform (MDSP): insights pré-clínicos e moleculares para o gerenciamento dos Cânceres de Cólon e Fígado
• Beneficiário: Guilherme Ribeiro Romualdo
• Modalidade de apoio: Auxílio à Pesquisa - Projeto Geração