Biocomposite-based fibrous scaffolds of natural rubber/polyhydroxybutyrate blend reinforced with 45S5 bioglass aiming at biomedical applications

Autor(es)

Silva, Michael J. ; Dias, Yasmin J. ; Zaszczynska, Angelika ; Robles, Jaqueline Rojas ; Abiade, Jeremiah ; Kowalczyk, Tomasz ; Kolbuk, Dorota ; Sajkiewicz, Pawel L. ; Yarin, Alexander L.

• Tipo de documento: Artigo Científico
• Fonte: Polymer Composites; v. N/A, p. 21-pg., 2023-10-09.

Resumo

The solution blow spinning technique was used to fabricate a new biocomposite fibrous mat consisting of natural rubber (NR) and polyhydroxybutyrate (PHB) bioblend, with various loads of 45S5 bioglass (BG) particles. According to SEM analysis, NR fibers exhibited ribbon-like morphologies, whereas the addition of PHB resulted in improved fiber formation and a reduction in their diameter. In NR-PHB/BG biocomposites with varying BG loadings, typical thermal degradation events of PHB (stage i) and NR (stage ii) were observed. In comparison with pure PHB, the TG/DTG curves of NR-PHB/BG specimens revealed a lower stage i degradation peak. Such an outcome is possibly due to the fact that PHB in the NR-PHB fibers is located predominantly at the surface, that is, PHB is more susceptible to thermal degradation. The NR-PHB/BG biocomposite possessed an increased stiffness due to the addition of PHB and BG, resulting in an increased stress and a decreased strain at rupture compared to the pure NR and NR-PHB mats. DMA analysis revealed two well-defined regions, above and below the glass transition temperature (T-g), for the storage modulus (E') of the NR-PHB/BG specimens. The values of E' were in both regions for NR-PHB/BG specimens increased at higher BG content. The measured tan delta = E ''/E' was used to determine the T-g value for all specimens, with T-g found to be in the -49 to -46 degrees C range. Finally, NR-PHB/BG biocomposite fibrous were proven noncytotoxic by in-vitro testing on fibroblasts. These biocomposites enhanced cell growth, holding great promise for tissue engineering applications. (AU)

• Processo FAPESP: 21/10512-5 - Biocompósitos trifásicos à base de borracha natural reforçados com nanowhiskers de celulose e biovidro obtidos pela técnica solution blowspinning
• Beneficiário: Michael Jones da Silva
• Modalidade de apoio: Bolsas no Exterior - Pesquisa