Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model

Autor(es)

Inada, Rafaela Nanami Handa ; Queiroz, Marcela Borsatto ; Lopes, Camila Soares ; Silva, Evelin Carine Alves ; Torres, Fernanda Ferrari Esteves ; da Silva, Guilherme Ferreira ; Guerreiro-Tanomaru, Juliane Maria ; Cerri, Paulo Sergio ; Tanomaru-Filho, Mario

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 27, n. 7, p. 15-pg., 2023-04-04.

Resumo

ObjectivesThis study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM).Materials and methodsDentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey's tests (p < 0.05).ResultsIRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (p < 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (p < 0.05).ConclusionsBIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids. (AU)

• Processo FAPESP: 17/14305-9 - Avaliação de novas substâncias para irrigação de canais radiculares e de cimentos endodônticos à base de silicato de cálcio
• Beneficiário: Juliane Maria Guerreiro Tanomaru
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/19049-0 - Avaliação das etapas do tratamento de canais radiculares, e das propriedades físico-químicas e biológicas de materiais à base de silicato tricálcico
• Beneficiário: Mario Tanomaru Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular