| Texto completo | |
| Autor(es): |
Feitor, Jessica F.
;
Brazaca, Lais C.
;
Lima, Amanda M.
;
Ferreira, Vinicius G.
;
Kassab, Giulia
;
Bagnato, Vanderlei S.
;
Carrilho, Emanuel
;
Cardoso, Daniel R.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACS BIOMATERIALS SCIENCE & ENGINEERING; v. 9, n. 5, p. 15-pg., 2023-04-04. |
| Resumo | |
Globalization has raised concerns about spreading diseases and emphasized the need for quick and efficient methods for drug screening. Established drug efficacy and toxicity approaches have proven obsolete, with a high failure rate in clinical trials. Organ-on-a-chip has emerged as an essential alternative to outdated techniques, precisely simulating important characteristics of organs and predicting drug pharmacokinetics more ethically and efficiently. Although promising, most organ-ona-chip devices are still manufactured using principles and materials from the micromachining industry. The abusive use of plastic for traditional drug screening methods and device production should be considered when substituting technologies so that the compensation for the generation of plastic waste can be projected. This critical review outlines recent advances for organ-on-a-chip in the industry and estimates the possibility of scaling up its production. Moreover, it analyzes trends in organ-on-a-chip publications and provides suggestions for a more sustainable future for organ-on-a-chip research and production. (AU) | |
| Processo FAPESP: | 17/01189-0 - Novel aging: tecnologias e soluções para fabricar novos produtos lácteos para um envelhecimento saudável |
| Beneficiário: | Daniel Rodrigues Cardoso |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/19750-3 - Explorando a detecção C4D para o desenvolvimento de biossensores microfluídicos inovadores e de baixo custo |
| Beneficiário: | Laís Canniatti Brazaca |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/18188-0 - Inativação fotodinâmica da Pneumonia Bacteriana utilizando nebulização do fotossensibilizador e iluminação extracorpórea |
| Beneficiário: | Giulia Kassab |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |