Visible-Light Mediated Carbamoylation of Nitrones under a Continuous Flow Regime

Autor(es)

Oliveira, Pedro H. R. ; Tordato, Everton A. ; Velez, Jeimy A. C. ; Carneiro, Pablo S. ; Paixao, Marcio W.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Organic Chemistry; v. 88, n. 10, p. 13-pg., 2023-05-19.

Resumo

Herein, we report a rapid and scalable continuous-flowphotocatalyticapproach for the carbamoylation of nitrones. This protocol makes useof readily available 4-amido-1,4 dihydropyridines as carbamoyl radicalprecursors. The scope of this transformation exhibits high compatibilitywith complex structures containing amino acids, peptides, and glycosides.Importantly, the developed method allows a photocatalytic syntheticstrategy in combination with flow conditions, maximizing the potentialand efficiency for the synthesis of valuable alpha-(N-hydroxy)-amino amides. (AU)

• Processo FAPESP: 21/06099-5 - Desenvolvimento de novas metodologias fotoquímicas para síntese de pequenas moléculas e modificações de biomoléculas
• Beneficiário: Márcio Weber Paixão
• Modalidade de apoio: Auxílio à Pesquisa - Regular