Terpenes extracted from marine sponges with antioxidant activity: a systematic review

Autor(es)

Martignago, Cintia Cristina Santi ; Soares-Silva, Beatriz ; Parisi, Julia Risso ; Silva, Lais Caroline Souza e ; Granito, Renata Neves ; Ribeiro, Alessandra Mussi ; Renno, Ana Claudia Muniz ; de Sousa, Lorena Ramos Freitas ; Aguiar, Anna Caroline Campos

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCTS AND BIOPROSPECTING; v. 13, n. 1, p. 12-pg., 2023-12-01.

Resumo

Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea organisms. The sponge's secondary metabolites demonstrated various bioactivities and potential pharmacological properties. This systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in vitro. The review was performed in accordance with PRISMA guidelines. The main inclusion criterion for analysis was articles with identification of compounds from terpene classes that demonstrate antioxidant activity in vitro. Searching in three different databases, two hundred articles were selected. After screening abstracts, titles and evaluating for eligibility of manuscripts 14 articles were included. The most performed analyzes to detect antioxidant activity were scavenging activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) and measurement of intracellular reactive oxygen species (ROS). It was possible to identify 17 compounds of the terpene class with pronounced antioxidant activity in vitro. Scientific evidence of the studies included in this review was accessed by the GRADE analysis. Terpenes play an important ecological role, moreover these molecules have a pharmaceutical and industrial application. (AU)

• Processo FAPESP: 19/10228-5 - Rede interdisciplinar para o desenvolvimento biotecnológico de biomateriais de origem marinha para uso na saúde humana: acometimentos patológicos do sistema osteoarticular
• Beneficiário: Ana Claudia Muniz Renno
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/19708-0 - Identificação de novos compostos antimaláricos: uma estratégia multidisciplinar visando a busca por classes ativas contra novos alvos moleculares e diferentes estágios de vida do Plasmodium spp
• Beneficiário: Anna Caroline Campos Aguiar
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores