Leukemia stem cell immunophenotyping tool for diagnostic, prognosis, and therapeutics

Autor(es)

de Rezende, Marina Mastelaro ; Ferreira, Alice T. ; Paredes-Gamero, Edgar J.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Cellular Physiology; v. 235, n. 6, p. 10-pg., 2019-11-10.

Resumo

The existence of cancer stem cells is debatable in numerous solid tumors, yet in leukemia, there is compelling evidence of this cell population. Leukemic stem cells (LSCs) are altered cells in which accumulating genetic and/or epigenetic alterations occur, resulting in the transition between the normal, preleukemic, and leukemic status. These cells do not follow the normal differentiation program; they are arrested in a primitive state but with high proliferation potential, generating undifferentiated blast accumulation and a lack of a mature cell population. The identification of LSCs might guide stem cell biology research and provide key points of distinction between these cells and their normal counterparts. The identification and characterization of the main features of LSCs can be useful as tools for diagnosis and treatment. In this context, the aim of the present review was to connect immunophenotype data in the main types of leukemia to further guide technical improvements. (AU)

• Processo FAPESP: 15/24464-1 - Aspectos subcelulares da sinalização de Ca2+ no controle da proliferação da célula-tronco hematopoética por interleucina-3 e pelo fator estimulador de colônias de granulócitos/macrófago
• Beneficiário: Marina Mastelaro de Rezende
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/23787-4 - Sinalização Wnt e de cálcio em células hematopoiéticas tronco normais e leucêmicas
• Beneficiário: Marina Mastelaro de Rezende
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado