Therapeutic applications and delivery systems for triptolide

Autor(es)

Viegas, Juliana Santos Rosa ; Praca, Fabiola Garcia ; Kravicz, Marcelo ; Bentley, Maria Vitoria Lopes Badra

• Tipo de documento: Artigo Científico
• Fonte: DRUG DELIVERY AND TRANSLATIONAL RESEARCH; v. 10, n. 6, p. 17-pg., 2020-08-13.

Resumo

Triptolide (TPL) is a natural compound and active component ofTripterygium wilfordiiHook F., an Asian native woody vine widely used for over 200 years in Chinese medicine. Hot water, ethanol-ethyl acetate, and chloroform-methanol extracts are the first reported TPL preparations in the literature, and since then, several studies for application in inflammation processes and cancer are described due to the antitumor, anti-inflammatory, and immunosuppressive characteristics of the molecule. However, physicochemical properties such as poor solubility and bioavailability are the main concerns regarding the TPL safety and efficacy in clinical studies since trials have reported adverse side effects alongside the excellent TPL therapeutic effects. Here, we review the main TPL applications and issues related to the drug usage, and a comprehensive summary of diseases is provided. Special emphasis is given to drug delivery systems designed to overcome the TPL physicochemical characteristics such as poor drug solubility, and how to increase efficacy and obtain a safe drug profile. (AU)

• Processo FAPESP: 19/04448-2 - Desenvolvimento de carreador lipídico nanoestruturado contendo pool de siRNAs associados à agente antitumoral como uma abordagem terapêutica multifuncional para o Câncer de pele
• Beneficiário: Juliana dos Santos Rosa
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático