Tongue hamartomas in pediatric patients: an international case series and literature review

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Perez-de-Oliveira, Maria Eduarda ; Robinson, Liam ; Junior, Jose Narciso Rosa Assuncao ; Abrahao, Aline Correa ; Romanach, Mario Jose ; Penafort, Paulo Victor Mendes ; Silva, Luan Cesar da ; Santos-Silva, Alan Roger ; Lopes, Marcio Ajudarte ; Heerden, Willie F. P. van ; Vargas, Pablo Agustin

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 134, n. 6, p. 10-pg., 2022-12-03.

Resumo

This study reports 9 additional tongue hamartomas in children paired with a literature review. A retrospective analysis was per-formed from 3 Oral Pathology laboratories. Additionally, a literature review was conducted through 5 electronic databases and gray literature. A total of 9 cases were identified in the retrospective analysis. Females outnumbered males with a ratio of 1.25:1. The age of presentation ranged from 2 weeks to 7 years. The posterior dorsum tongue was the most affected subsite (n = 4). One case was seen in a patient with oro-facial-digital syndrome, 2 cases in patients with cleft palates, and one case with an encephalo-cele. The most common predominant component was salivary gland tissue (n = 4). A literature search included 79 pediatric patients presenting with 95 tongue hamartomas. A slight female (n = 47) predilection was observed, with ages varying from 15 hours to 19 years. The posterior tongue dorsum (n = 31) was the most affected site. Seven cases were seen in association with syndromes. The most common predominant component was smooth muscle (n = 35). Although hamartomas are rare in the oral cavity, they should be considered in the differential diagnosis of masses involving the posterior tongue dorsum in children. (Oral Surg Oral Med Oral Pathol Oral Radiol 2022;134:739-748) (AU)

• Processo FAPESP: 19/26676-7 - Desvendando o papel da translocação CRTC1-MAML2 no Carcinoma Mucoepidermoide de glândula salivar: um estudo clínico-patológico, molecular e proteômico
• Beneficiário: Maria Eduarda Pérez de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado