| Texto completo | |
| Autor(es): |
Ferreira, Natalia S.
;
Lima, Nathalia F.
;
Sulczewski, Fernando B.
;
Soares, Irene S.
;
Ferreira, Marcelo U.
;
Boscardin, Silvia B.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | European Journal of Immunology; v. N/A, p. 15-pg., 2023-05-24. |
| Resumo | |
Regulatory and effector cell responses to Plasmodium vivax, the most common human malaria parasite outside Africa, remain understudied in naturally infected populations. Here, we describe peripheral CD4(+) T- and B-cell populations during and shortly after an uncomplicated P. vivax infection in 38 continuously exposed adult Amazonians. Consistent with previous observations, we found an increased frequency in CD4(+)CD45RA(-)CD25(+)FoxP3(+) T regulatory cells that express the inhibitory molecule CTLA-4 during the acute infection, with a sustained expansion of CD21(-)CD27(-) atypical memory cells within the CD19(+) B-cell compartment. Both Th1- and Th2-type subsets of CXCR5(+)ICOS(hi)PD-1(+) circulating T follicular helper (cTfh) cells, which are thought to contribute to antibody production, were induced during P. vivax infection, with a positive correlation between overall cTfh cell frequency and IgG antibody titers to the P. vivax blood-stage antigen MSP1(19). We identified significant changes in cell populations that had not been described in human malaria, such as an increased frequency of CTLA-4(+) T follicular regulatory cells that antagonize Tfh cells, and a decreased frequency of circulating CD24(hi)CD27(+) B regulatory cells in response to acute infection. In conclusion, we disclose a complex immunoregulatory network that is critical to understand how naturally acquired immunity develops in P. vivax malaria. (AU) | |
| Processo FAPESP: | 18/07142-9 - Influência das Vias de Sinalização de STAT1, STAT3, STAT5 e STAT6 em Células Dendríticas Convencionais na Instrução da Resposta de Células T Auxiliares |
| Beneficiário: | Silvia Beatriz Boscardin |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/18740-9 - Bases científicas para a eliminação da malária residual na Amazônia Brasileira |
| Beneficiário: | Marcelo Urbano Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 16/50108-0 - Desenvolvimento de ferramentas de soro-vigilância para detecção de infecções por Plasmodium vivax e monitoramento para controle e eliminação da malária em países da região amazônica |
| Beneficiário: | Irene da Silva Soares |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |