Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review

Autor(es)

Kimura, Talita de Carvalho ; de Lima-Souza, Reydson Alcides ; Scarini, Joao Figueira ; Lavareze, Luccas ; Abu Egal, Erika Said ; Altemani, Albina ; Mariano, Fernanda Viviane

• Tipo de documento: Artigo Científico
• Fonte: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. N/A, p. 9-pg., 2023-07-05.

Resumo

In this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched to access cases of SPA in salivary glands. One hundred and thirty cases of SPA were found across 61 selected articles. SPA affected mainly the parotid gland of adults with a mean age of 44.6 years old, with a slight preference for females. The lesion was usually presented as a painless firm mass with a long period of evolution. Histologically, they are well-delimitated lesions composed of acinar and ductal elements with a variety of cytomorphologic features surrounded by a densely collagenized stroma. PI3K was the most common gene mutation related to SPA. SPA is a benign condition that mainly affects the parotid gland of female patients and it is usually treated by surgical resection with a good prognosis. (AU)

• Processo FAPESP: 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 19/09419-0 - Alterações genômicas na transformação maligna do Adenoma Pleomorfo
• Beneficiário: João Figueira Scarini
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 20/08431-4 - Análise do perfil metabolômico na transformação maligna do adenoma pleomórfico
• Beneficiário: Reydson Alcides de Lima Souza
• Modalidade de apoio: Bolsas no Brasil - Doutorado