Impacts of Different Prenatal Supplementation Strategies on the Plasma Metabolome of Bulls in the Rearing and Finishing Phase

Autor(es)

Polizel, Guilherme Henrique Gebim ; Fernandes, Aricia Christofaro ; Furlan, Edison ; Prati, Barbara Carolina Teixeira ; Ferraz, Jose Bento Sterman ; Santana, Miguel Henrique de Almeida

• Tipo de documento: Artigo Científico
• Fonte: METABOLITES; v. 13, n. 2, p. 14-pg., 2023-02-01.

Resumo

This study investigated the effects of maternal nutrition on the plasma metabolome of Nellore bulls in the rearing and finishing phases, and metabolic differences between these phases. For this study, three nutritional approaches were used in 126 cows during pregnancy: NP-(control) mineral supplementation; PP-protein-energy supplementation in the final third; and FP-protein-energy supplementation during the entire pregnancy. We collected blood samples from male offspring in the rearing (450 +/- 28 days old) and finishing phases (660 +/- 28 days old). The blood was processed, and from plasma samples, we performed the targeted metabolome analysis (AbsoluteIDQ((R)) p180 Kit). Multiple linear regression, principal component analysis (PCA), repeated measures analysis over time, and an enrichment analysis were performed. PCA showed an overlap of treatments and time clusters in the analyses. We identified significant metabolites among the treatments (rearing phase = six metabolites; finishing phase = three metabolites) and over time (21 metabolites). No significant metabolic pathways were found in the finishing phase, however, we found significant pathways in the rearing phase (Arginine biosynthesis and Histidine metabolism). Thus, prenatal nutrition impacted on plasma metabolome of bulls during the rearing and finishing phase and the different production stages showed an effect on the metabolic levels of bulls. (AU)

• Processo FAPESP: 21/03265-1 - Uso de ferramentas da biologia de sistemas na avaliação dos efeitos da programação fetal em bovinos de corte
• Beneficiário: Guilherme Henrique Gebim Polizel
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/12105-2 - Fenômica da programação fetal na produção de bovinos de corte: uma abordagem sistêmica
• Beneficiário: Miguel Henrique de Almeida Santana
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores