| Texto completo | |
| Autor(es): |
Oliveira, Carlos Henrique de Moura
;
Neto, Joao Honorato de Araujo
;
Elenna, Javier Alcides
;
Oliver, Josidel Conceicao
;
Dias, Amanda Latercia Tranches
;
Caldas, Ivo Santana
;
Doriguetto, Antonio Carlos
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Molecular Structure; v. 1282, p. 15-pg., 2023-03-01. |
| Resumo | |
Sulfamethoxazole (SMZ) and sulfadiazine (SDZ) drugs belong to class II or IV synthetic antibiotics, which require higher doses for oral-administered formulations. Since, the multiplication and multi-factorial drug formulations are interesting tool to overcome such limitations, two poly-iodide salts of those two drugs, namely, SMZ[I5].H2O and SDZ2[I4] are presented herein. The systematic characterizations by powder X-ray diffraction, Fourier transform infrared, ultraviolet/visible spectroscopy, differential thermal analysis, thermogravimetry and single X-ray crystal structures of the SMZ[I5].H2O and SDZ2[I4] are presented. Sul-fonamidepolyiodide salts were tested in vitro against Escherichia coli, Pseudomonas aeruginosa, Staphylo-coccus aureus, Candida tropicalis, Candida krusei, and Candida albicans to show the enhanced antimicrobial activity of the SMZ[I5].H2O in comparison with unmodified sulfonamide (SMZ).(c) 2023 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 21/04876-4 - Estudos sobre estrutura & atividade de complexos de RuII/areno/mercaptoligantes frente ao câncer |
| Beneficiário: | João Honorato de Araujo Neto |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |