In vivo Raman spectroscopy for breast cancer: diagnosis in animal model

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Bitar, R. ; Martins, M. A. ; Ribeiro, D. ; Carvalho, C. ; Santos, E. A. P. ; Ramalho, L. N. Z. ; Ramalho, F. ; Martinho, H. ; Martin, A. A. ; MahadevanJansen, A ; Petrich, W ; Alfano, RR ; Katz, A

• Tipo de documento: Artigo Científico
• Fonte: MEDICAL IMAGING 2007: PACS AND IMAGING INFORMATICS; v. 6853, p. 7-pg., 2008-01-01.

Resumo

Raman spectroscopy has been well established as a powerful method for studying biological tissues and diagnosing diseases. In this study we have developed a breast cancer animal model and collected in vivo Raman spectra of mammary glands of 27 Sprague-Dawley female rats treated with DMBA and 5 non-treated used as control group. A dispersive Raman spectrometer with a @785 nm laser excitation coupled a fiber optic probe and a CCD detector was used to obtain the spectra. The obtained in vivo transcutaneous Raman spectra have shown important differences between normal and abnormal tissues when acquired from one side to the other side of the lesion. (AU)

• Processo FAPESP: 05/58565-7 - Espectroscopia raman in vivo no estudo do carcinoma mamario induzido em modelo animal: implicacoes para biopsia optica
• Beneficiário: Renata Andrade Bitar
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 01/14384-8 - Estudo de células neoplásicas por espectroscopia de infravermelho próximo
• Beneficiário: Airton Abrahao Martin
• Modalidade de apoio: Auxílio à Pesquisa - Regular