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Thrombin Inhibitors from Different Animals

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Autor(es):
Tanaka-Azevedo, A. M. ; Morais-Zani, K. ; Torquato, R. J. S. ; Tanaka, A. S.
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY; v. N/A, p. 9-pg., 2010-01-01.
Resumo

Venous and arterial thromboembolic diseases are still the most frequent causes of death and disability in high-income countries. Clinical anticoagulants are inhibitors of enzymes involved in the coagulation pathway, such as thrombin and factor Xa. Thrombin is a key enzyme of blood coagulation system, activating the platelets, converting the fibrinogen to the fibrin net, and amplifying its self-generation by the activation of factors V, VIII, and XI. Thrombin has long been a target for the development of oral anticoagulants. Furthermore, selective inhibitors of thrombin represent a new class of antithrombotic agents. For these reasons, a number of specific thrombin inhibitors are under evaluation for possible use as antithrombotic drugs. This paper summarizes old and new interests of specific thrombin inhibitors described in different animals. (AU)

Processo FAPESP: 10/51659-4 - Thrombin inhibitors from different animals
Beneficiário:Anita Mitico Tanaka-Azevedo
Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo