Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis

Autor(es)

Scarel-Caminaga, Raquel M. ; Curtis, Karen M. C. ; Renzi, Rivelto ; Sogumo, Patricia M. ; Anovazzi, Giovana ; Viana, Aline C. ; Kim, Yeon J. ; Orrico, Silvana R. P. ; Cirelli, Joni A.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE; v. 10, p. 5-pg., 2011-01-01.

Resumo

Background: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+ 860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings: Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05). Conclusions: The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. (AU)

• Processo FAPESP: 05/03231-7 - Investigação de polimorfismos no promotor do gene interleucina 8 em indivíduos com doença periodontal crônica
• Beneficiário: Yeon Jung Kim
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 06/04492-1 - Investigacao de polimorfismos no gene interleucina 8 e seus receptores em individuos com doenca periodontal cronica.
• Beneficiário: Karen Maria de Carvalho Curtis
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 03/10424-0 - Investigação de polimorfismos no gene interleucina 8 e seus receptores em indivíduos com doença periodontal crônica
• Beneficiário: Raquel Mantuaneli Scarel Caminaga
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/04553-8 - Investigação de polimorfismos no gene da interleucina 10 em indivíduos com periodontite agressiva
• Beneficiário: Patrícia Mayumi Sogumo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica