Online Monitoring of Electrochemical Degradation of Paracetamol through a Biomimetic Sensor

Autor(es)

Quintino de Oliveira, Mariana Calora ; de Vasconcelos Lanza, Marcos Roberto ; Paz Jara, Jose Luis ; Taboada Sotomayor, Maria Del Pilar

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF ELECTROCHEMISTRY; v. 2011, p. 11-pg., 2011-01-01.

Resumo

This paper reports, for the first time, the online monitoring to the electrochemical degradation of the paracetamol using a biomimetic sensor coupled to a Flow Injection Analysis (FIA) system. The electrochemical degradation of the drug was carried out in aqueousmediumusing a flow-by reactor with a DSA anode. The process efficiency wasmonitored at real time by the biomimetic sensor constructed by modifying a glassy carbon electrode with a Nafion membrane doped with iron tetrapyridinoporphyrazine (FeTPyPz). Simultaneously, we carried out off-line analysis by liquid chromatography ( HPLC) during the experiments in order to validate the proposed system. In addition, to investigate the degradation products of the paracetamol electrolysis, we used the techniques of UPLC/MS and GC/MS. (AU)

• Processo FAPESP: 08/00303-5 - Construção de sensores biomiméticos para determinação de fármacos e seu acoplamento a sistemas em fluxo
• Beneficiário: Maria Del Pilar Taboada Sotomayor
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/05899-3 - Acoplamento de um Sensor Biomimético com um Reator Eletroquímico para Monitoramento "on line" da Degradação Eletroquímica de Paracetamol
• Beneficiário: Mariana Calora Quintino de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica