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Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status

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Zanchi, Nelo Eidy ; Almeida, Felipe Natali ; Lira, Fabio Santos ; Rosa Neto, Jose Cesar ; Nicastro, Humberto ; da Luz, Claudia Ribeiro ; de Siqueira Filho, Mario Alves ; Felitti, Vitor ; Vainzof, Mariz ; Seelaender, Marilia ; Poortmans, Jacques R. ; Lancha, Antonio Herbert, Jr.
Número total de Autores: 12
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC WORLD JOURNAL; v. N/A, p. 7-pg., 2012-01-01.
Resumo

Physical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. These conditions belong to the "diseasome of physical inactivity". In contrast, the protective effect of regular exercise against diseases associated with chronic inflammation may to some extent be ascribed to an anti-inflammatory effect. The so called "acute exercise threshold", the complex mixture of several variables involved in exercise, such as type, volume, frequency, and intensity range is capable of inducing positive physiological adaptations and has been specifically addressed in the recent literature. The major concern is related to the level of the threshold: "exercise training shifts from a therapeutic adaptive intervention to one with potential pathological consequences". Nonetheless, if the mechanical stimulus is too weak to disrupt cellular homeostasis, training adaptations will not occur. Answering these questions could present practical applications, especially during inflammatory diseases associated with detrimental muscle effects and could theoretically constitute a "new" therapeutic approach to treat/improve an inflammatory state. This paper aims to describe specific data from the literature regarding the effects of exercise on inflammatory diseases in order to promote a more sophisticated perspective on the anti-inflammatory effects of exercise. (AU)

Processo FAPESP: 08/51090-1 - Efeito do treinamento fisico de forca e da suplementacao com leucina sobre a resposta atrofica da musculatura esqueletica induzida pelo uso de dexametasona.
Beneficiário:Antonio Herbert Lancha Junior
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/07062-3 - Leucina e desuso muscular: eficácia clínica anti-atrófica e mecanismos relacionados
Beneficiário:Humberto Nicastro Silva
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto