FCGR3B*03 allele inheritance pattern in Brazilian families and some new variants of gene FCGR3B

Autor(es)

Terzian, Claudia C. N. ; Chiba, Akemi K. ; Santos, Viviani C. ; Silva, Neusa P. ; Bordin, Jose O.

• Tipo de documento: Artigo Científico
• Fonte: Transfusion; v. 52, n. 3, p. 6-pg., 2012-03-01.

Resumo

BACKGROUND: The FCGR3B gene encoding the FcyRIIIb receptor for immunoglobulin G has three polymorphic forms known as HNA-1a, HNA-1b, and HNA-1c, encoded by the alleles FCGR3B*01, FCGR3B*02, and FCGR3B*03, respectively. It is not clear whether the inheritance of the FCGR3B*03 allele, which encodes the HNA-1c, is linked or not to the other two alleles. The objective of this study was to identify the inheritance pattern of the FCGR3B*03 allele in Brazilians. (AU)

• Processo FAPESP: 05/55237-9 - Aspectos clínicos e moleculares de antígenos e anticorpos de células sanguíneas
• Beneficiário: Jose Orlando Bordin
• Modalidade de apoio: Auxílio à Pesquisa - Temático