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| Autor(es): Mostrar menos - |
Cunha, Nayanne Larissa
;
de Mendonca Uchoa, Camila Jacintho
;
Cintra, Lucas Silva
;
de Souza, Herbert Cristian
;
Peixoto, Juliana Andrade
;
Silva, Claudia Peres
;
Magalhaes, Lizandra Guidi
;
Meleiro Gimenez, Valeria Maria
;
Groppo, Milton
;
Rodrigues, Vanderlei
;
da Silva Filho, Ademar Alves
;
Andrade e Silva, Marcio Luis
;
Cunha, Wilson Roberto
;
Pauletti, Patricia Mendonca
;
Januario, Ana Helena
Número total de Autores: 15
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Evidence-based Complementary and Alternative Medicine; v. 2012, p. 8-pg., 2012-01-01. |
| Resumo | |
Miconia langsdorffii Cogn. (Melastomataceae), Roupala montana Aubl. (Proteaceae), Struthanthus syringifolius (Mart.) (Loranthaceae), and Schefflera vinosa (Cham. & Schltdl.) Frodin (Araliaceae) are plant species from the Brazilian Cerrado whose schistosomicidal potential has not yet been described. The crude extracts, fractions, the triterpenes betulin, oleanolic acid, ursolic acid and the flavonoids quercetin 3-O-beta-D-rhamnoside, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-glucopyranosyl-(1-2)-alpha-L-rhamnopyranoside and isorhamnetin 3-O-beta-D-glucopyranosyl-(1-2)-alpha-L-rhamnopyranoside were evaluated in vitro against Schistosoma mansoni adult worms and the bioactive n-hexane fractions of the mentioned species were also analyzed by GC-MS. Betulin was able to cause worm death percentage values of 25% after 120 h (at 100 mu M), and 25% and 50% after 24 and 120 h (at 200 mu M), respectively; besides the flavonoid quercetin 3-O-beta-D-rhamnoside promoted 25% of death of the parasites at 100 mu M. Farther the flavonoids quercetin 3-O-beta-D-glucoside and quercetin 3-O-beta-D-rhamnoside at 100 mu M exhibited significantly reduction in motor activity, 75% and 87.5%, respectively. Biological results indicated that crude extracts of R. montana, S. vinosa, and M. langsdorffii and some n-hexane and EtOAc fractions of this species were able to induce worm death to some extent. The results suggest that lupane-type triterpenes and flavonoid monoglycosides should be considered for further antiparasites studies. (AU) | |
| Processo FAPESP: | 08/01268-9 - Estudo fitoquímico e avaliação das atividades antimalárica, antimicrobiana e de inibição da enzima acetilcolinesterase de espécies nativas do cerrado do estado de São Paulo |
| Beneficiário: | Ana Helena Januário |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/60132-4 - Investigação das atividades esquistossomicida, tripanocida e leishmanicida de lignanas e neolignanas obtidas por acoplamento oxidativo in vitro de fenilpropanóides |
| Beneficiário: | Ademar Alves da Silva Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 09/00604-8 - Moléculas de interesse: isolamento, identificação, modificações estruturais e avaliação em diversos ensaios biológicos |
| Beneficiário: | Wilson Roberto Cunha |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |