Transfer of Maternal Immunity to Newborns of Diabetic Mothers

Autor(es)

Franca, Eduardo Luzia ; Paranhos Calderon, Iracema de Mattos ; Vieira, Elisa Lima ; Morceli, Glilciane ; Honorio-Franca, Adenilda Cristina

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL & DEVELOPMENTAL IMMUNOLOGY; v. N/A, p. 7-pg., 2012-01-01.

Resumo

This study was carried out with hyperglycemic pregnant women to investigate the transfer of antibody classes to newborns across the placenta or by colostrum and the functional activity of phagocytes in maternal blood, cord blood, and colostrum from diabetes mothers. Samples from maternal blood, cord blood, and colostrum were collected from 20 normoglycemic and 20 hyperglycemic pregnant women. We determined antibodies levels, superoxide release, phagocytosis and bactericidal activity of phagocytes. We demonstrated that IgG levels in cord blood were higher in the hyperglycemic group. IgA and IgM levels were higher in maternal than in cord blood samples. Plasma antibody levels were lower in hyper- than in normoglycemic women. The colostrum of diabetic mothers had lower IgA and IgG levels. Colostrum and maternal blood phagocytes when exposed to EPEC increased the superoxide release. Cord blood phagocytes of hyperglycemic group, independently of bacteria, had higher superoxide release. Colostrum and blood phagocytes from diabetic group exhibited some phagocytic and microbicidal activity in response to EPEC. Mononuclear phagocytes from cord blood had the lowest phagocytosis, and bactericidal activity for EPEC, regardless of glycemic status. These data showed that hyperglycemia altered IgG transfer across the placenta and decreases immunoglobulin levels in maternal blood and colostrum. (AU)

• Processo FAPESP: 09/01188-8 - Atividade funcional de fagócitos do leite de mães hiperglicêmicas leve e diabéticas e sua regulação neuroimunoendocrinológica.
• Beneficiário: Glilciane Morceli
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/18045-5 - Imunologia das interações materno-fetais no Diabetes e hiperglicemia leve: transferência passiva de componentes imunoreativos do sangue materno e do colostro para o recém-nascido
• Beneficiário: Iracema de Mattos Paranhos Calderon
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/09187-8 - Atividade funcional de fagócitos do leite de mães hiperglicêmicas leve e diabéticas e sua regulação neuroimunoendocrinológica
• Beneficiário: Iracema de Mattos Paranhos Calderon
• Modalidade de apoio: Auxílio à Pesquisa - Regular