Anacardic Acids from Cashew Nuts Ameliorate Lung Damage Induced by Exposure to Diesel Exhaust Particles in Mice

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Nicoletti Carvalho, Ana Laura ; Annoni, Raquel ; Lobo Torres, Larissa Helena ; Cardoso Santos Durao, Ana Carolina ; Borges Shimada, Ana Lucia ; Almeida, Francine Maria ; Hebeda, Cristina Bichels ; Quirino Santos Lopes, Fernanda Degobbi Tenorio ; Dolhnikoff, Marisa ; Martins, Milton Arruda ; Ferraz Silva, Luiz Fernando ; Poliselli Farsky, Sandra Helena ; Nascimento Saldiva, Paulo Hilario ; Ulrich, Cornelia M. ; Owen, Robert W. ; Marcourakis, Tania ; Salles Trevisan, Maria Teresa ; Mauad, Thais

• Tipo de documento: Artigo Científico
• Fonte: Evidence-based Complementary and Alternative Medicine; v. 2013, p. 13-pg., 2013-01-01.

Resumo

Anacardic acids from cashew nut shell liquid, a Brazilian natural substance, have antimicrobial and antioxidant activities and modulate immune responses and angiogenesis. As inflammatory lung diseases have been correlated to environmental pollutants exposure and no reports addressing the effects of dietary supplementation with anacardic acids on lung inflammation in vivo have been evidenced, we investigated the effects of supplementation with anacardic acids in a model of diesel exhaust particle-(DEP-) induced lung inflammation. BALB/c mice received an intranasal instillation of 50 mu g of DEP for 20 days. Ten days prior to DEP instillation, animals were pretreated orally with 50, 150, or 250mg/kg of anacardic acids or vehicle (100 mu L of cashew nut oil) for 30 days. The biomarkers of inflammatory and antioxidant responses in the alveolar parenchyma, bronchoalveolar lavage fluid (BALF), and pulmonary vessels were investigated. All doses of anacardic acids ameliorated antioxidant enzyme activities and decreased vascular adhesion molecule in vessels. Animals that received 50mg/kg of anacardic acids showed decreased levels of neutrophils and tumor necrosis factor in the lungs and BALF, respectively. In summary, we demonstrated that AAs supplementation has a potential protective role on oxidative and inflammatory mechanisms in the lungs. (AU)

• Processo FAPESP: 07/05033-3 - Efeito dos ácidos anacárdicos no sistema respiratório de camundongos submetidos à instilação intranasal de partículas resultantes da combustão de diesel
• Beneficiário: Ana Laura Nicoletti Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto