| Texto completo | |
| Autor(es): |
Miyake, Juliano Andreoli
;
Benadiba, Marcel
;
Ribeiro, Geise
;
Silva, Denise De Oliveira
;
Colquhoun, Alison
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ANTICANCER RESEARCH; v. 34, n. 4, p. 11-pg., 2014-04-01. |
| Resumo | |
Aim: Gliomas are primary brain tumours. Gamma-linolenic acid (GLA) exerts anti-proliferative effects. Several ruthenium-containing complexes have antiproliferative effects and can be used as adjuvant therapies in cisplatin-resistant cancer. The present study reports on the anti-proliferative properties and effects on tumour morphology of a novel diruthenium-GLA complex (Ru(2)GLA) and its comparison with GLA in the C6 rat glioma model both in vitro and in vivo. Materials and Methods: In vitro and in vivo experiments were performed on C6 glioma rat cells, and in an orthotopic model. Results: Ru(2)GLA (100 mu M) appears to be an inhibitor of C6 rat glioma cell proliferation. The nuclear area of Ru(2)GLA-treated cells was 2.18-times larger than that of control cells, suggesting DNA replication occurred but mitosis was blocked in the G(2)-M phase. Ru(2)GLA (2 mM) inhibited C6 cell proliferation in vivo and the changes in tumor morphology confirm both cellular uptake and collagen fibre-binding in the extracellular matrix. Conclusion: Ru(2)GLA appears to be a low-toxicity drug and a potential candidate for anti-proliferative therapy of glioma. (AU) | |
| Processo FAPESP: | 09/53573-2 - Estudo do efeito biologico e antitumoral de um novo composto dirutenico contendo ibuprofeno in vitro e in vivo |
| Beneficiário: | Alison Colquhoun |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 05/60596-8 - Espécies complexas com potencial aplicação em bioinorgânica, catálise, farmacologia e química ambiental: concepção, preparação, caracterização e reatividade |
| Beneficiário: | Ana Maria da Costa Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 11/06592-1 - Metalofármacos anti-inflamatórios e antitumorais: reatividade, propriedades e interações com matrizes hospedeiras biocompatíveis |
| Beneficiário: | Denise de Oliveira Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |