An overview of amines as nutritional supplements to counteract cancer cachexia

Autor(es)

de Campos-Ferraz, Patricia Lopes ; Andrade, Isabel ; das Neves, Willian ; Hangai, Isabela ; Rodrigues Alves, Christiano Robles ; Lancha, Antonio Herbert, Jr.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE; v. 5, n. 2, p. 6-pg., 2014-06-01.

Resumo

Cancer cachexia is a complex multifactorial syndrome characterized by loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Recently, some amino acids and other amine dietary supplements have been highlighted in medical field due to positive effects upon diseases evolving skeletal muscle atrophy. Therefore, the aim of this brief review is to discuss the putative application of amines as dietary supplements to counteract skeletal muscle wasting on cancer cachexia. Specifically, we focus in two nutritional supplements: (1) branched-chain amino acids (BCAAs) and (2) creatine. Both BCAAs and creatine may attenuate proteolysis and enhance proteins synthesis in skeletal muscle. Although more experimental studies and clinical trials are still necessary to elucidate this therapeutic application, several evidences have demonstrated that amines supplementation is a promising coadjuvant treatment to cancer cachexia. (AU)

• Processo FAPESP: 12/02682-9 - Suplementação de creatina em ratos portadores do Tumor de Walker 256
• Beneficiário: Patricia Lopes de Campos-Ferraz
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/04744-4 - Efeitos do treinamento de força no músculo esquelético em ratos com caquexia induzida pelo câncer
• Beneficiário: Willian das Neves Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 12/07319-0 - Efeito da suplementação alimentar na melhora da densidade mineral óssea
• Beneficiário: Antonio Herbert Lancha Junior
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 12/25240-1 - Efeitos do treinamento físico aeróbio intervalado em alta intensidade no músculo esquelético de ratos inoculados com o tumor Walker 256
• Beneficiário: Christiano Robles Rodrigues Alves
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado