| Texto completo | |
| Autor(es): Mostrar menos - |
Gimenes, C.
;
Gimenes, R.
;
Rosa, C. M.
;
Xavier, N. P.
;
Campos, D. H. S.
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Fernandes, A. A. H.
;
Cezar, M. D. M.
;
Guirado, G. N.
;
Cicogna, A. C.
;
Takamoto, A. H. R.
;
Okoshi, M. P.
;
Okoshi, K.
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF DIABETES RESEARCH; v. 2015, p. 10-pg., 2015-01-01. |
| Resumo | |
We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary diabetes (DM-Sed), and exercised diabetes (DM-Ex). Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m/min, 18 min/day. Myocardial function was evaluated in left ventricular (LV) papillary muscles and oxidative stress in LV tissue. Statistical analysis was given by ANOVA or Kruskal-Wallis. Echocardiogram showed diabetic groups with higher LV diastolic diameter-to-body weight ratio and lower posterior wall shortening velocity than controls. Left atrium diameter was lower in DM-Ex than DM-Sed (C-Sed: 5.73 +/- 0.49; C-Ex: 5.67 +/- 0.53; DM-Sed: 6.41 +/- 0.54; DM-Ex: 5.81 +/- 0.50 mm; P < 0.05 DM-Sed vs C-Sed and DM-Ex). Papillary muscle function was depressed in DM-Sed compared to C-Sed. Exercise attenuated this change in DM-Ex. Lipid hydroperoxide concentration was higher in DM-Sed than C-Sed and DM-Ex. Catalase and superoxide dismutase activities were lower in diabetics than controls and higher in DM-Ex than DM-Sed. Glutathione peroxidase activity was lower in DM-Sed than C-Sed and DM-Ex. Conclusion. Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats. (AU) | |
| Processo FAPESP: | 09/54506-7 - Efeitos do bloqueio precoce da aldosterona na estrutura e funcao cardiaca e na composicao da matriz colagena miocardica de ratos espontaneamente hipertensos. |
| Beneficiário: | Katashi Okoshi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |