Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes

Autor(es)

Fraga-Silva, Thais F. C. ; Marchetti, Camila M. ; Mimura, Luiza A. N. ; Locachevic, Gisele A. ; Golim, Marjorie A. ; Venturini, James ; Arruda, Maria S. P.

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; v. 2015, p. 10-pg., 2015-01-01.

Resumo

Dermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes. Our results showed two distinct profiles of fungal outcome and immune response. Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance. Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-alpha by PAC. Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1(+) monocytes into the peripheral blood, long term HH mice showed low percentage of these cells. Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity. (AU)

• Processo FAPESP: 09/50654-1 - Contribuição ao estudo da dermatofitose experimental: determinação das subpopulações de monócitos e macrófagos em camundongos HH infectados com Trichophyton mentagrophyte
• Beneficiário: Maria Sueli Parreira de Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/50818-4 - Estudo do estado de ativação de macrófagos peritoneais e sua relação com a evolução de lesões subcutâneas: possível tráfego de células entre a cavidade peritoneal e o tecido comprometido
• Beneficiário: Thais Fernanda de Campos Fraga da Silva
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 09/52911-1 - Influencia da condicao hiperglicemica/hipoinsulinemica na evolucao da dermatofitose murina. determinacao das subpopulacoes de monocitos em camundongos hiperglicemicos/hipoinsulinemicos infectado com trichop...
• Beneficiário: Camila Martins Marchetti
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica