| Texto completo | |
| Autor(es): |
Cunha, Rodrigo L. O. R.
;
Ferreira, Edgard A.
;
Oliveira, Camila S.
;
Omori, Alvaro T.
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOTECHNOLOGY ADVANCES; v. 33, n. 5, p. 10-pg., 2015-09-01. |
| Resumo | |
The kinetic resolution of racemates and desymmetrization are the most common approaches to the preparation of enantiomerically enriched compounds. These procedures allow the access of high valuable, chiral building blocks for many purposes in academic or industrial R&D endeavors. Nevertheless, the scope of stereochemistry recognition in biotransformations usually occurs at the site of the transformation or when it is close to it (not more than 3 bonds). However, there are a growing number of enzymatic transformations which surpass the limits of stereorecognition of remote chiral (or prochiral) centers. In this account, we would like to present some aspects of biocatalyzed remote resolutions and remote desymmetrizations to call attention for these challenging transformations. (C) 2015 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 09/00617-2 - Biocatálise: uso de células vegetais e lipases em síntese orgânica - aplicação em síntese assimétrica de compostos com atividade biológica |
| Beneficiário: | Alvaro Takeo Omori |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |