Synthesis of 1,3,4-oxadiazole derivatives from alpha-amino acid and acyl hydrazides under thermal heating or microwave irradiation conditions

Autor(es)

Dornelles, Luciano ; Rodrigues, Oscar E. D. ; Heck, Elisiane F. ; Bender, Caroline R. ; Cansian, Mariane B. ; Schwab, Ricardo S. ; Severo Filho, Wolmar A.

• Tipo de documento: Artigo Científico
• Fonte: ARKIVOC; v. N/A, p. 14-pg., 2015-01-01.

Resumo

A series of new 2,5-disubstituted 1,3,4-oxadiazoles was synthesized under conventional thermal heating and microwave irradiation conditions through the reaction of acyl hydrazides with N-protected a-amino acid in presence of a small amount of POCl3. Heterocycles were obtained in moderate to good yields and in relatively short reaction times. (AU)

• Processo FAPESP: 13/06558-3 - Catálise metálica assimétrica: preparação de alcoóis quirais e seus derivados a partir de reagentes orgânicos de zinco poli-funcionalizados e aplicação de novos ligantes quirais suportados em nanopartículas magnéticas
• Beneficiário: Ricardo Samuel Schwab
• Modalidade de apoio: Auxílio à Pesquisa - Regular